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Indian Institute of Science Education and Research Berhampur

BIO 202: Molecular Biology and Developmental Biology (Credit, 3)

Course Contents:

Molecular Biology: Genetic information and its expression

1. DNA replication
2. Transcription and processing of RNA
3. Translation and post-translational processes leading to synthesis of mature proteins
4. Protein targeting and sorting,
5. RNA replication, reverse transcription
6. Regulation of gene expression

Developmental Biology: Formation of the organism using the genetic information

1. 1. Introduction to Developmental Biology
   -Historical perspective of embryology
   -Theory of preformation, epigenesis and recapitulation
   -Principles of developmental Biology

2 . Evolutionary Developmental Biology (Evo-Devo)

1. -Mechanisms of diversification of body forms.
2. -Concepts of Heterotopy, Heterochrony, Heterometry and Heterotypy.

3. Development from fertilization to germ layer formation

1. Gamete structure, development and fertilization
2. -Cleavage and gastrulation in Xenopus
3. -Axis formation of Xenopus

4. Genetic basis of Development

1. Spatiotemporal patterns of gene expression.
2. Morphogens and gradients.

5. Introduction to cell signalling – basic concept

Suggested Books:

• Molecular Cell Biology, 8th Edition. by Harvey Lodish et al.,
• Life: The Science of Biology, Vol. I Ninth Edition by David E. Sadava et al.,
• Biological Science by Scott Freeman et al.,
• James D. Watson, et al., Molecular Biology of the Gene, 7th edition,
• Bruce Alberts et al., Molecular Biology of the cell 6th Edition
• Scott F Gilbert, Developmental Biology

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