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Indian Institute of Science Education and Research Berhampur

BIO 302: Biochemistry I - Advanced Enzymology (Credit, 4)

Course Contents:

An introduction to enzymes: A historical perspective, rate of a reaction, activation energy, introduction to enzyme kinetics, Km, Vmax and Kcat calculation, Enzyme inhibition (Competitive and non competitive), IC50, Allostery, cooperativity, Hill’s coefficient; Mechanism of enzyme action,

Molecular mechanism of enzyme function,

Ribozymes: discovery, mechanism of action, structural and evolutionary perspective, RNA World Hypothesis.

Structure and Catalysis: Biochemical interactions,

Prosthetic groups, coenzymes and cofactors, NAD, FAD. Vitamins. Mechanism of energy production: mitochondrial electron transport chain and Chemo-osmotic theory;

Suggested Books:

• Principles of Biochemistry: Lehninger, Nelson and Cox; 5th edition, W.H. Freeman; 2008.
• Biochemistry: Lubert Stryer; W. H. Freeman; 7th Edition; 2010.
• Biochemistry by Donald Voet, Judith G. Voet; Wiley; 4th edition; 2010.
• The Biophysical Chemistry of Nucleic Acids and Proteins: Thomas E. Creighton; Helvetian Press; 2010.

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