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Indian Institute of Science Education and Research Berhampur

BIO 303: Structural Biology (Credit, 4)

Course Contents:

Proteins from primary to quaternary structures: Amino acids, primary sequence, peptide bond, dihedral angle, Geometry and chemistry of di-peptide, Ramachandran map, Secondary structural elements and their geometric description.

Structural biology and evolution; Protein domain evolution

Protein Data Bank

Thermodynamics

Protein structure, function and mechanism, Structural classification of proteins, Examples of protein three dimensional structures, Protein-Ligand and Protein-Protein interactions,

chaperones, membrane proteins; Collagen triple helix, Super secondary structure, Structural domains, Quaternary association of globular proteins; Protein purification and quantification

Current topics in structural biology: membrane protein structure, protein folding and degradation.

Basics of nucleic acid structure: The building blocks, DNA secondary structure: the Double Helix, Deviation from the ideal geometry, tertiary structure of RNA;

Suggested Reading::

• Biochemistry: Lubert Stryer; W. H. Freeman; 7th Edition; 2010.
• Introduction to Protein Structure: Carl Branden and John Tooze; Garland Science; 2nd edition; 1999.

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