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Indian Institute of Science Education and Research Berhampur

BIO 303: Biochemistry I (3)

Learning Objectives:

Biochemistry course will help student appreciate various chemical processes that occur in biological systems and their regulation by biocatalyst called enzymes. This course will emphasize on how the entire machinery is coordinated by various biochemical activities inside the cell.

Course Contents:

Bioenergetics, Biological oxidation reduction reactions, ATP and its role in various metabolic processes; Functions of various proteins: Immunoglobulin, Oxygen carrier proteins, An introduction to enzymes: Mechanism of enzyme action, introduction to enzyme kinetics, Km, Vmax and Kcat calculation, Enzyme inhibition (Competitive and non competitive), IC50, Allostery, cooperativity, Hill’s coefficient; Biological Membranes and Transport: The composition and architecture of membranes, membrane dynamics,Transporter proteins solute transport across membranes; Cell signaling- Receptors and second messenger; Metabolic pathways; Glycolysis, gluconeogenesis, pentose phosphate pathway and their regulations; TCA/Kreb’s cycle and its regulation: Production of Acetyl-CoA, reactions of the Citric Acid Cycle Glyoxylate pathway.

Suggested Books:

• Principles of Biochemistry: Lehninger, Nelson and Cox; W.H. Freeman; 5th edition; 2008.
• Biochemistry: Lubert Stryer; W. H. Freeman; 7th Edition; 2010.
• Biochemistry by Donald Voet, Judith G. Voet; Wiley; 4th edition; 2010.
• The Biophysical Chemistry of Nucleic Acids and Proteins: Thomas E. Creighton; Helvetian Press; 2010.

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