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Indian Institute of Science Education and Research Berhampur

Biological Sciences

BIO 311: Cell Signaling and Stress Biology (3)

Prerequisites: BIO 301: Cell Biology

Basic introduction to signaling, components of signaling, ligand and receptor concept. Types of ligand (soluble/insoluble, abiotic/biotic etc), post translational modification and signal regulation. Signal amplifiers, second messengers and molecular pathways for signal transduction Types receptors (Soluble and membrane bound) Ion channels, receptors with associated enzymatic activities. Various cellular processes involving signaling and its consequences. Signaling in bacteria and plant, Two component system (Histidine kinase receptor). G-protein coupled receptors, heterotrimeric G-proteins and associated signaling pathways. Receptor tyrosine kinase, growth factor signaling, JAK-STAT and MAP kinase pathway. Receptor like kinases (RLK’s) in plants.

Stress signaling and regulation of stress induced gene expression, different types of stress (Temperature extremes, high salt, bright light, pH, oxidative stress, desiccation stress, heavy metal, xenobiotic stress as well as biotic stress such as herbivory, insect attack, bacterial and viral infection), stress proteins and their functions, molecular chaperones, mechanism of stress perception, tolerance and avoidance. Basal and acquired stress tolerance. Regulation of protein homeostasis during stress, ER stress and unfolded protein response, examples of high level of stress tolerance in different organisms​ and understanding the genetic and molecular basis of stress tolerance. Manipulation of specific stress associated proteins for production of stress tolerant organisms. Mental stress and its consequences in mammals with special emphasis on humans.      

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