# Office of Academic AffairsIndian Institute of Science Education and Research Berhampur

Biological Sciences

BIO 313: Biostatistics (Credit, 4)

Course Content:

• • Probability Distributions: Normal distribution: Properties, Measures of location and dispersion: Descriptive statistics: (Mean, mode, median, quartile, standard deviation, standard error, coefficient of variation, skewness and kurtosis) Poisson distribution and Binomial distribution
• Confidence Intervals and Hypothesis testing (Confidence levels; concept and rationale of null hypothesis; Type- I and Type-II errors and their interpretation and measurement)
• Field Sampling and Experimental Designs (random, systematic, and stratified sampling; replication, pseudoreplication, controls, paired-sample designs, factorial designs, etc.)
• Null hypothesis and significance testing
• One sample test: Student’s t-test
• Paired-sample t-test
• Analysis of Variance: One-way ANOVA (Analysis and F-testing; Multiple comparisons among means – a priori and a posteriori tests; Assumptions of ANOVA)
• Analysis of Variance: Two-way ANOVA (Significance testing for factor interaction)
• Analysis of variance: Randomized block designs and Repeated Measures designs
• Correlation
• Linear Regression
• Brief introduction to logistic, curvilinear and multiple regressions
• Analysis of frequencies: Tests for goodness of fit and for independence ( 2 and Likelihood ratio tests)
• Power of a statistical test
• Nonparametric Tests (Mann-Whitney U-test, Wilcoxon signed-rank test, Spearman’s Rank Correlation test, Kruskall-Wallis Test)
• Brief introduction to Bayesian Statistics

Suggested Books:

• Baldi, B., and D. S. Moore, 2017. The practice of statistics in the life sciences. 3 rd ed. Freeman Publisher
• Lee, J. H., 2003. Introductory Biostatistics, Wiley-Interscience.
• Pagano, M., and K. Gauvreau, 2000. Principles of Biostatistics. 2 nd ed. Indian Edition. Brooks/Cole
• Sokal, R. R., and F. J. Rohlf, 1995. Biometry. 3 rd ed., Freeman Publishers.
• Whitlock, M.C. and D. Schluter, 2015, The analysis of biological data. W. H. Freeman Publishers.
• Zar, J. H., 2014. Biostatistical analysis. 5 th ed. Pearson Publ.