IISERBPR:Course Content

Biological Sciences

BIO 406: Cancer Biology (DE, Credit, 3)

Course Content:

Section I: Introduction to Cancer BiologyAetiology and Epidemiology: History/Mechanisms that lead to cancer Cell division: aneuploidy, polyploidy and chromosomal translocations, consequential uncontrolled growth and cancer; Nature of cancer
Section II: Cancer GeneticsTumorigenesis: Environmental/Lifestyle/Genetics Carcinogens, DNA damage and mutagenesis; Inherited susceptibility to cancer; Genomic integrity and development of cancer; Cancer cell cycle and tumor suppressor proteins, cell signaling; Cellular Oncogenes, Tumor viruses and mechanisms of oncogenesis
Section III: Cancer Epigenetics, Signalling Pathways and MetabolismHallmarks of cancer: Cell cycle, Metabolic deregulation, Cell signaling mitogens and dysregulation of pathways in cancer; Growth factors and associated signaling pathways in cancer;, Metastasis, Immune cells, cytokines and growth hormones
Section IV: Cancer Diagnosis, Therapeutics, ToxicologyPathology: Detection/Diagnosis Therapeutic strategies: Signalling pathways, Immune system, Genetic and Epigenetic alterations, Energetics, Future of cancer biology: Success in terms of early diagnosis, prevention, drug targets, challenges such as heterogeneity of cells, tumour/stroma cross talk,

Suggested Books:

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