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Research article published in in Chemical Communications

Research article published in in Chemical Communications

Congratulations to Dr. Shikha Gandhi and team for their research publications in Chemical Communications


Pd/Brønsted acid catalysed intramolecular N-allylation of indoles and pyrroles with alkynes for the synthesis of N-fused heterocycles by Saswat Ranjan Bhoi, Chhanda Debnath and Shikha Gandhi, https://doi.org/10.1039/D3CC05023H

Abstract

We, herein, report a Pd(0) and Brønsted acid-catalyzed redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes for the synthesis of biologically important imidazolidinone-fused N-heterocycles. The allylation is completely atom-economical and is applicable to a wide range of substrates. The methodology eliminates the use of a leaving group or an oxidizing agent, often employed for the allylation of nucleophiles. To the best of our knowledge, N-allylation of indoles and pyrroles with alkynes has not been reported to date.


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