Debendra K. Mohapatra completed his PhD at CSIR-IICT in 1999 and pursued post-doctoral studies in USA. After his post doctoral studies, he joined NCL, Pune, as a Scientist (2002-2008). During this period, he has also visited to USA (Different Universities and Industries under Business Development Program) and worked in UK Universities as a Visiting Scientist [Cambridge (Prof. Steven V. Ley) and Oxford (Prof. Mark G. Moloney)]. He has collaborated with Prof. R. H. Grubbs (Nobel Laureate, California Institute of Technology), Prof. Steven V. Ley (Cambridge University), Prof. Mark. G. Moloney (Oxford University), and Prof. Ronald T. Raines (University of Wisconsin). In 2008, he moved to CSIR-IICT and working as a Chief Scientist. Dr. Debendra K. Mohapatra’s research interest is in organic chemistry with a special emphasis on the asymmetric total synthesis of complex natural products of medicinal importance. He has corrected close to eight natural product structures with his ingenuity skill over synthetic route as well as on data analysis. He has developed innovative synthetic pathways for the access of complex natural products and carved a niche for himself in the realm of organic synthesis as well as in applied research (developed industrially viable process chemistry for MRI contrast agent, Misoprostol, Bedaquiline, Orlistat etc.). He has also achieved Innocentive Award ($35,000) for developing one of the best technologies for trans-4-fluoro-L-proline in collaboration with D & O Pharmachem Inc. He has keen interest in teaching and grooming students which can ensure a safe and organized learning space where students can thrive by stimulating critical thinking, enhance their skills, knowledge, and promote active participation. He has more than 170 papers in reputed international journals. His research work has been recognized by several awards and recognitions. Currently, he is working as a Professor in the Department of Chemical Sciences at Indian Institute Science Education and Research Berhampur.
At IISER Berhampur, our research program is at the forefront of advancing chemical reactions for the total synthesis of biologically active natural products. We specialize in developing novel reaction methodologies for creating one or more new asymmetric centres, application of these methodologies toward the synthesis of complex natural products, synthesizing simple analogues for medicinal chemistry purpose, and creating target-oriented small molecule libraries. Our core areas of expertise include:
Ø Asymmetric Total Synthesis of Biologically Active Natural Products: We focus on developing innovative synthetic pathways to produce complex natural products with significant biological activities leading to the confirmation or revision of the structure including stereochemistry. In addition, making them accessible in more quantities for both research and therapeutic applications.
Ø Development of Simple and Novel Methodologies: Our work aims to create new and simple reaction methodologies that enhance the efficiency, selectivity, and scalability of chemical processes with respect to industry demands.
Ø Process Development and Scale-up: We bridge the gap between laboratory-scale reactions and industrial-scale processes leading to new technology development and technology transfer for commercialization, ensuring that our research can be practically applied in real-world settings.
Ø Medicinal Chemistry: By synthesizing intricate analogues, we contribute to drug discovery and development, working to design new therapeutic agents with improved efficacy.
Ø Peptide Synthesis and Peptidomimetics: We also specialize in the synthesis of peptides and their mimetics, expanding the possibilities for drug development.
Our team is dedicated to pushing the boundaries of chemical science, advancing both academic research and practical innovations that ultimately benefit society.
