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Dr. Pravat Kumar Parida

Assistant Professor

Biological Sciences

pravatparida@iiserbpr.ac.in

9123847166

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Academic Background

  • Ph.D.(Biochemistry), Bose Institute, Affiliated to the University of Calcutta, West Bengal

  • M.Sc.(Life Science), National Institute of Technology, Rourkela, Odisha

Professional Experience 

  • University of Texas Southwestern Medical Center, Dallas, Texas, USA

Awards and Memberships

  • 2019-till date-Associate Member-American Association for Cancer Research

Research Interests

  • Metabolic Diseases

  • Cancer Metastasis

  • Tumor Microenvironment

  • Drug Discovery

Research Group

  • Alok Dubey, Ph.D. Scholar

  • Rishabh Biswas, Ph.D. Scholar

About me

I am passionate about exploring the role of small molecule metabolites in human diseases. By utilizing mass spectrometry-based techniques, including targeted and untargeted metabolomics and fluxomics, I aim to uncover critical metabolic insights into human diseases.

Biography

Dr. Parida completed his bachelor's degree in Zoology from Fakir Mohan University, Balasore, in 2009. He then pursued a master’s degree in Life Science from NIT-Rourkela, graduating in 2011. He earned his Ph.D. in Biochemistry from Bose Institute (affiliated with the University of Calcutta), Kolkata, in 2019.

In 2019, he joined Malladi lab at UT Southwestern Medical Center in Dallas, Texas, USA, to engage himself in cutting-edge research on breast cancer brain metastasis. This venture allowed him to contribute to the ongoing efforts to understand and combat cancer metastasis. 

Dr. Parida’s future endeavors are directed toward the exploration of Metabolic Diseases, Cancer Metastasis, Tumor Microenvironment, Drug Discovery, and Drug Delivery. By exploring these critical domains, he aspires to contribute significantly to advancing our understanding of these complex phenomena and, ultimately, make meaningful strides in improving healthcare outcomes. 

Research Projects

  • Understanding the Molecular and Metabolic Drivers of Metastatic Breast Cancer

Metastasis contributes to more than 90% of cancer-related deaths as finding effective treatment is a significant clinical challenge. Although some progress has been made in recent years, there is still much to understand about the mechanisms behind metastasis. Dr. Parida’s “Cancer Metastasis and Therapeutics Lab” is dedicated to discovering new targets and pathways that drive metastasis of cancer cells and developing novel therapeutic strategies to improve patient care. Additionally, the lab focuses on exploring the roles of cellular components like mitochondria, endoplasmic reticulum, and ribosomes in cancer metastasis and understanding how metabolic diseases such as obesity and diabetes contribute to it. Through the integration of various research approaches, including cell lines, animal models, and multi-omics (metabolomics, transcriptomics, proteomics, and epigenomics), along with drug design and discovery tools, the lab aims to offer fresh insights and therapeutic interventions to combat metastatic cancer. 

  • Decoding the Connection: Exploring Rewired Amino Acid Metabolism in Breast Cancer Brain Metastasis and its Modulation by Neuro-Metabolic Crosstalk.

This investigation will provide insights into the intricate relationship between rewired amino acid metabolism and cancer metastasis, specifically examining how neuro-metabolic crosstalk influences these changes. By understanding this complex interplay, we gain insights into the mechanisms driving cancer's adaptation to the brain environment, ultimately shaping the course of metastasis. Decoding these connections may uncover potential biomarkers, aiding in early diagnosis and intervention. Ultimately, this research holds the promise of advancing our understanding of metastatic breast cancer, leading to improved therapies and better outcomes for patients with brain metastasis. 

  • Investigating the Effect of Indian Diet Habits on Metabolic Diseases 

Indian dietary patterns are diverse and rich, but changes in lifestyle and diet have led to an increasing prevalence of metabolic diseases. Understanding how traditional diets influence metabolic health can inform preventive strategies and dietary interventions. This research is important for addressing the rising global burden of metabolic diseases, including Obesity, Diabetes, and Cardiovascular conditions. It may also guide the development of culturally tailored interventions to promote healthier eating habits, ultimately contributing to improved public health outcomes in India and beyond. 

Key Publications

  • Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness. Parida, P.K., Marquez-Palencia, M., Nair, V., Kaushik, A.K., Kim, K., Sudderth, J., Quesada-Diaz, E., Cajigas, A., Vemireddy, V., Gonzalez-Ericsson, P.I., Malladi, S*. et al. (2022). Cell Metabolism 34, 90-105 e107.(I.F. 29.0).

  • Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases. Parida, P.K., Marquez-Palencia, M., Ghosh, G., Khandelwal, N., Kim, K., Malladi, S.* et al. (2023). Nature Cancer, 4, 893–907. (I.F. 23.18).

  • Inhibition of cancer progression by a novel trans-stilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. Parida, P.K., Mahata, B., Santra, A., Chakraborty, S., Ghosh, Z., Raha, S., Misra, A.K., Biswas, K. *, and Jana, K. * (2018). Cell Death Disease 9, 448. (I.F. 9.00).

  • Cell Competition Shapes Metastatic Latency and Relapse.Kim, K., Huang, H., Parida, P.K., He, L., Marquez-Palencia, M., Reese, T.C., Kapur, P., Brugarolas, J., Brekken, R.A., and Malladi, S*. (2023). Cancer Discovery 13(1):85-97. (I.F. 28.2).

  • AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer. Marquez-Palencia M., Herrera L.Z., Parida, P.K., Ghosh S., Kim, K., Davis A. J., Malladi, S*. et al. (2024). Cancer Research. (I.F. 11.2).

Contact Details

Full Name

Pravat Kumar Parida


Email

pravatparida@iiserbpr.ac.in


Contact

9123847166