bigimage
Dr. Rakesh Kumar Pathak

Assistant Professor

Chemical Sciences

rkpathak@iiserbpr.ac.in

+91 7999 301 185

   

Research Projects

  • Metal-Drug Conjugates and Their Lipid-Polymer Blended Nanoscale Composites for Drug Delivery: 

    Cancer is the second most commonly diagnosed disease in India. In recent times, India has been ranked as 2nd in terms of high cancer-related mortality to incidence ratio. The exact mechanism for the cellular action of many important anticancer drugs remains unknown. Investigating and understanding the mechanistic aspects of newly designed drug conjugates for targeted action is required for improving the therapeutic regimen for cancer. 

    Metal ions with distinct features, such as multi-valency, biocompatibility, and therapeutic relevance, can be used to develop new drug conjugates as a combination therapeutic regimen. We plan to engineer the individual drugs on to a single metal ion platform in a manner that the drugs stabilize to form a new species designated as metal-drug conjugates (MDCs). These conjugates will be entrapped into stable nanoparticle core for sustained and efficacious deliver

  •  Multifaceted Platinum-Based Therapeutics and Engineering of Antibody-Drug Conjugates for Targeted Therapy of Cancer: 

    Targeted therapies have emerged as an attractive approach to cancer treatment and offer the ability to deliver potent cytotoxic drugs specifically to tumor site and reduces side effect. However, this type of therapy is still not much explored for treatment of various cancer. Of late, the interest to use, platinum (Pt) based chemotherapeutic drugs have emerged as adjuvant therapy for many cancers including breast and pancreatic cancer treatment. Among Pt based drugs, cisplatin and oxaliplatin are the most effective chemotherapeutic agents used to treat 50% of all cancers including breast cancer. 

    However, in recent times platinum agents faces tremendous challenge of drug resistance, severe toxicity and side effects. In this scenario, a targeted delivery of platinum drugs using completely biological systems, expected to revolutionize treatment regimens for many solid tumors. Antibody-drug-conjugates (ADCs) can be an endowed molecular approach to deliver highly potent drugs using monoclonal antibodies to the targeted tissues. This project is in collaboration with cancer biologist and translational research scientist and aimed to develop platinum-based ADCs for better therapeutic outcomes in men and women suffering from cancer.

Contact Details

Full Name

Rakesh Kumar Pathak


Email

rkpathak@iiserbpr.ac.in


Contact

+91 7999 301 185


Address

IISER Berhampur