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ଭାରତୀୟ ବିଜ୍ଞାନ ଶିକ୍ଷା ଏବଂ ଗବେଷଣା ସଂସ୍ଥାନ ବ୍ରହ୍ମପୁର

भारतीय विज्ञान शिक्षा एवं अनुसंधान संस्थान बरहमपुर

Indian Institute of Science Education and Research Berhampur

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Dr. Thirupathi Barla

Associate Professor

Chemical Sciences

thirupathibarla@iiserbpr.ac.in

0680 2227762

Personal Website

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Additional Responsibility

  • Associate Dean, Academic Affairs

Publications All

Academic Background

  • M.Sc. (Organic Chemistry) Osmania University, 2006-2008

  • PhD.: CSIR-Indian Institute of Chemical Technology, Hyderabad, 2009-2014

  • Postdoctoral studies: Harvard University, Cambridge, USA, Advisor: Prof. E. J. Corey, 2015-2018.

Professional Experience 

  • Associate Professor: Department of Chemical Sciences, IISER Berhampur, Feb. 2024-Present.

  • Assistant Professor: Department of Chemical Sciences, IISER Berhampur, July 2018 - Feb. 2024.

  • Associate Research Scientist, Sai Life Sciences, Hyderabad, India; March 2014-Feb. 2015.

  • Research Chemist, Aragen Life Sciences Formerly Known as GVK BIO Sciences, Hyderabad, India​; May 2008-March 2009.

Awards and Memberships

  • Thieme Chemistry Journal Award-2023

  • Postdoctoral fellowship from Harvard University, USA, 2015-2018

  • Senior Research Fellowship, CSIR-UGC; 2011-2014. Junior Research Fellowship, CSIR-UGC; 2009-2011

  • Best performance award from Aragen Life Sciences formerly known as GVK-Biosciences in 2009

Research Interests

  • Organic Synthesis

  • Total Synthesis of Natural Products

  • Aryne Chemistry

  • Asymmetric Synthesis

Research Group

  • Mr. Sudip Mandal PhD Scholar; (2019-2024)

  • Ms. Gitanjali Mishra (2020-Till date) Mr. Sayantan Kundu, iPhD (2022-Till date) Mr. Nityaprakash PhD Scholar (2022-Till date) Mr. Biral Kanti Pal, PhD Scholar (2022-Till date)

About me

 

Through his research, teaching, and publications, Dr. Barla is a committed, knowledgeable, and capable researcher. He has developed a solid reputation among students and colleagues alike. He has over 15 years of research experience in synthetic organic and medicinal chemistry. He worked in various pharmaceutical industries in process and medicinal chemistry, which shaped him into a successful researcher in synthetic chemistry and related areas.

 

 

Biography

 

Dr. Barla Thirupathi was born in Madavelli, Manchirial district, Telangana, India in 1984. After completing his M.Sc. (Organic Chemistry) from Osmania University (2006-2008), he worked as a research chemist at Aragen Life Sciences, formerly known as GVK-Biosciences, Hyderabad (2008-2009). In early 2009, he joined as a Junior Research Fellow (JRF) at CSIR-Indian Institute of Chemical Technology, Hyderabad, with Dr. Debendra K. Mohapatra for his doctoral studies (2009-2015). Afterwards, he worked as an associate research scientist in the process R&D division at Sai Life Sciences, Hyderabad. Then, Dr. Thirupathi moved to Harvard University as a postdoctoral fellow to work with Nobel laureate Prof. E. J. Corey (2015-2018), where he developed highly active fluorinated second-generation oxazaborolidine catalysts and applied them in enantioselective Diels-Alder reactions. In July 2018, he moved back to India and joined as an assistant professor of chemistry at one of India's premier institutes, the Indian Institute of Science Education and Research (IISER) Berhampur. Dr. Thirupathi has already been recognized as an upcoming independent researcher and has received various accolades, including the 2023 Thieme Chemistry Journals Award.

 

 

 

Key Publications

2025


32.    Mandal, S.; Kundu, S.; Thirupathi, B.* Total Synthesis, Determination of Absolute Configuration, Antibacterial Efficacy of Colletotrichumolide, and Its 3R-Diastereomer,  Journal of Organic Chemistry, 2025, 90, 7902–7909.

https://pubs.acs.org/doi/10.1021/acs.joc.5c00832


31. Kundu, S.; Mandal, S.; Thirupathi, B.* Kobayashi’s Aryne Precursor for the One-Step Synthesis of Anthraquinones and Its Application to the Total Synthesis of Chrysophanol, Danthron, and Physcion, Journal of Organic Chemistry, 2025, 90, 2472–2478.

https://pubs.acs.org/doi/10.1021/acs.joc.4c03041

 

30.    Mishra, G.; Indu, P.; Sasmal, M.; Thirupathi, B.* Synthesis of Sulfone Containing-Spirocycles, -Pentafulvene Dyes and Their Photophysical Properties (Invited article), European Journal of Organic Chemistry, 2025, e202401311

https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202401311

 

29.     Pal, B. K.; Sahoo, K.; Sourav D., Ruthrotha S. B., Thirupathi, B.* Rapid Assembly of 1,3-Dicarbonyl Fused 5-phenyl-1-Azabicyclo[3.1.0]hexanes and Their Cytotoxic Activities, Organic Letters, 2025, 27, 761-766.

https://pubs.acs.org/doi/10.1021/acs.orglett.4c04394

 

28.     Mishra, G.; C. M, Y.,  Thirupathi, B*. Synthesis of Spirocyclic-1,3-indandione Containing-Cyclopentenones and -Benzotropones, Chemistry An Asian Journal, 2024, e202400667.

https://aces.onlinelibrary.wiley.com/doi/10.1002/asia.202400667

 

2024

 

27.    Sahoo, K.; Patra, N.; Dandela, R.; Thirupathi, B*. A Three-Component Synthesis of Spiropyrrolines. Journal of Organic Chemistry 2024, 89, 5337-5352.

https://pubs.acs.org/doi/full/10.1021/acs.joc.3c02713

 

26.     Mandal, S.; Mahananda, D.; Paladugu, D.; Thirupathi, B*. Total Synthesis and Determination of the Absolute Configuration of Berkeleylactone I. Journal of Organic Chemistry 2024, 89, 4165-4175.

https://pubs.acs.org/doi/10.1021/acs.joc.4c00178

 

25.  Mandal, S.; Mahananda, D.; Dey, S.; Bharathavikru, R. S.; Thirupathi, B*. Total Synthesis, Revised Structure, and Biological Evaluation of Elgonene B and Analogues. Journal of Natural Products 2024, 87, 152-159.

https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00988

 

 

24. Synform Interview of Barla Thirupathi as a Young Career Focus Presentation:  DOI: 10.1055/s-0040-1720624 Synform 2024/03, A41–A43

 

2023

 

 

23.     Mishra, G.; Sasmal, M.; Chakraborty, A.; Thirupathi, B*. Synthesis of Highly Functionalized Spirocycles and Pentafulvene-Containing Dyes Involving 2-(2′-ketoalkyl)-1,3-indandiones. Chemistry - A European Journal 2023, 29, e202301976.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202301976

 

22.     Hazra, G.; Kundu, S.; Dandela, R.; Thirupathi, B*. Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties. Journal of Organic Chemistry 2023, 88, 8493-8504.

https://pubs.acs.org/doi/10.1021/acs.joc.3c00462

 

21.     Hazra, G.; Dinesh, S.; Sahoo, K.; Thirupathi, B*. Recent advances with cobalt-mediated asymmetric hydrogenations. Results in Chemistry 2023, 5, Review. DOI: 10.1016/j.rechem.2023.100843

https://www.sciencedirect.com/science/article/pii/S2211715623000826?via%3Dihub

 

 

2022

 

20.     Pothireddy, M.; Hazra, G.; Babu, P. V.; Thirupathi, B*.; Dandela, R. Synthesis of Fluorinated 2-Benzylphthalazin-1(2 H)-one, 1-Phthalazinamine, and 1-Alkoxy/Benzyloxyphthalazine Derivatives by an Ultrasonication Method. Synlett 2022, 33, 1716-1722, Article. DOI: 10.1055/a-1846-5200

https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1846-5200

 

19.    Pothireddy, M.; Bhukta, S.; Babu, P. V.; Thirupathi, B*.; Dandela, R. Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction. Synthetic Communications 2022, 52, 564-576,

https://www.tandfonline.com/doi/full/10.1080/00397911.2022.2037651

 

18.    Mandal, S.; Thirupathi, B*. Total synthesis of proposed elgonene C and its (4R,5R)-diastereomer. Organic and Biomolecular Chemistry 2022, Article. DOI: 10.1039/d2ob00094f

https://pubs.rsc.org/en/content/articlelanding/2022/ob/d2ob00094f

 

17.     Hazra, G.; Mishra, G.; Dandela, R.; Thirupathi, B*. A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A. Journal of Organic Chemistry 2022, 87, 11925-11938.

https://pubs.acs.org/doi/10.1021/acs.joc.2c00340

 

16.   Thirupathi, B*.; Jena, B. K. Total Synthesis of (+)-Sacrolide A. ChemistrySelect 2019, 4, 2908-2911.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.201900192

 

2020

 

15.    Mandal, S.; Thirupathi, B*. Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis. Organic and Biomolecular Chemistry 2020, 18, 5287-5314.

https://pubs.rsc.org/en/content/articlelanding/2020/ob/d0ob00954g

 

 

14.    Thirupathi, B*.; Zilla, M. K. Syntheses and Biological Importance of Herboxidiene/GEX1A. ChemistrySelect 2019, 4, 11944-11958.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.201902742

 

2019

 

 

13.     Thirupathi, B*.; Jena, B. K. Total Synthesis of (+)-Sacrolide A. ChemistrySelect 2019, 4, 2908-2911.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.201900192


(Top downloaded article among work published between January 2018 and December 2019 in its journal)

Contact Details

Full Name

Thirupathi Barla

Email

thirupathibarla@iiserbpr.ac.in

Contact

0680 2227762

Address

IISER Berhampur

Personal Website

https://bthirupathi56.wixsite.com/website