Dr. Vivek Tiwari’s research is centered on exploring the clinically relevant but challenging-to-identify structural, metabolic and epigenetic events associated with brain disorders, with a particular focus on gliomas and dementia. Vivek’s research group employs multidisciplinary approaches to unravel the molecular underpinning of cancer initiation and progression, cognitive impairment and cerebral small vessel diseases. His study encompasses investigations in human patients, transgenic mouse model of brain diseases, cell and organoid models.
Dr. Vivek's research group at IISER Berhampur is developing novel metabolic models to generate in vivo metabolic maps in whole brain and tumor mass together with genetic and epigenetic correlates to understand the underpinning of structural heterogeneities in cancers, particularly gliomas. The multidisciplinary approaches being employed in his group encompass metabolic investigations in vivo clubbed with magnetic resonance imaging and spectroscopy, fiber tractography and cognitive biology, wrapped in artificial intelligence and metabolic modeling to identify clinically relevant hard-to-identify structural, neurovascular and neurometabolic signatures for improved clinical management of patients with brain disorders. His postdoctoral work in a multidisciplinary group of Physicists, Neurosurgeons and Neurooncologists allows him to envision his science from bench to bedside.
Vivek's group is closely working with clinical collaborators focused towards clinically challenging problems in Brain Tumors and Neurocognitive disorders.
To know more: https://sites.google.com/iiserbpr.ac.in/nibbrlab/home
1. Yadav, Neha, Jayshaan Baibhav, Seemadri Subhadarshini, Saroj Kumar Das Majumdar, Mohit K. Jolly, and Vivek Tiwari. "Brain metastases converge on shared geometric architecture and transcriptomic landscape yet remain distinct from gliomas." iScience 29, no. 4 (2026) Web-Link
2. Pandey S, Yadav N, Tiwari V* and Jagannathan NR (2026) Insight into the metabolism of gliomas by MRI and MRS. Biophysical Reviews, 2026; Web-Link
3. Gupta, N. K., Yadav, N., & Tiwari, V. (2025b). Brain aging and cognitive decline accelerate beyond a threshold of periventricular white matter hyperintensity. Cerebral Cortex, 35(11). https://doi.org/10.1093/cercor/bhaf302 Web-Link
4. Panigrahi A, Das NR, Yadav N, Panda S, Sethy AS, Panda SK, Mohakud NK, Tiwari V*. AI-Driven Quantitative Metabolomics for Early and Precise HIE Diagnosis: Challenges and Solutions. ACS Omega. 2025 Nov 24;10(48):57876- 57888. doi:10.1021/acsomega.5c03256. PMID: 41502645; PMCID: PMC12771435. Web-Link
5. Tiwari, V., Ganji, S. K., An, Z., Pinho, M. C., Davis, L. T., McKnight, C. D., Berry, J. D., Mobley, B. C., Luo, L. Y., Mohler, A. C., Merrell, R. T., Kelly, P. D., Thompson, R. C., Mickey, B. E., Malloy, C. R., Gore, J. C., Patel, T. R., Maher, E. A., & Choi, C. (2025). Magnetic resonance spectroscopy of 2‐Hydroxyglutarate and glycine in adult subjects with brainstem Gliomas. NMR in Biomedicine, 38(11), e70153. https://doi.org/10.1002/nbm.70153 Web-Link
6. Yadav N, Mohanty A, V A, Tiwari V. Fractal dimension and lacunarity measures of glioma subcomponents are discriminative of the grade of gliomas and IDH status. NMR in Biomedicine 2024 Oct 5. doi: 10.1002/nbm.5272. Epub ahead of print. PMID: 39367752. Web-Link
7. Yadav N, Gupta NK, Thakar D, Tiwari V. Magnitude and kinetics of a set of neuroanatomic volume and thickness together with white matter hyperintensity is definitive of cognitive status and brain age. Translational Psychiatry. 2024 Sep 27;14(1):389. doi: 10.1038/s41398-024-03097-2. PMID: 39333492; PMCID: PMC11437080. Web Link
8. Tiwari V, Daoud EV, Hatanpaa KJ, Gao A, Zhang S, An Z, Ganji SK, Raisanen JM, Lewis CM, Askari P, Baxter J, Levy M, Dimitrov I, Thomas BP, Pinho MC, Madden CJ, Pan E, Patel TR, DeBerardinis RJ, Sherry DA, Mickey BE, Malloy CR, Maher EA, Choi C. (2020) Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. Neuro-Oncology 2(7):1018-1029 Web Link
9. Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, and Choi C (2020) In Vivo detection of 2-Hydroxyglutarate in IDH mutant Mouse and human brain tumor. Magnetic Resonance in Medicine 84(3):1152-1160 Web Link
10. An Z, Tiwari V, Levy M, Hatanpaa K, Pan E, Maher EA, Patel TR, Mickey B, and Choi C (2019) 3D High-Resolution Imaging of 2-Hydroxyglutarate in Glioma Patients using DRAG-EPSI at 3T In Vivo. Magnetic Resonance in Medicine 81(2):795-802. Web Link
11. Tiwari V, An Z, Wang Y, Choi C (2018) Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3T In Vivo. Magnetic Resonance in Medicine 80(4):1307-1319. Web Link
12. Tiwari V, An Z, Ganji SK, Baxter J, Mickey B, Pan E, Maher EA, Pinho M and Choi C (2017) Measurement of Glycine in healthy and tumorous brain by triple- refocusing MRS at 3T In Vivo. NMR in Biomedicine 30: e3747 Web Link
13. Tiwari V, Veeraiah P, Subramaniam V, Patel AB (2013) Differential Effects of Ethanol on Regional Glutamatergic and GABAergic Neurotransmitter Pathways in Mouse Brain. Journal of Neurochemistry 128:628-640 Web Link
14. Tiwari, V., Ambadipudi, S., & Patel, A. B. (2013). Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. Journal of Cerebral Blood Flow & Metabolism, 33(10), 1523-1531. https://journals.sagepub.com/doi/full/10.1038/jcbfm.2013.114 Web-Link
