Designation: 
Assistant Professor
Department: 
Chemical Sciences
Phone: 
+91 680 2227 759
Academic Details:

Assistant Professor: Department of Chemical Sciences, IISER Berhampur, India. March. 2017 - present

Pelotonia Postdoctoral Fellow: The James Comprehensive Cancer Centre and Department of Pharmaceutics and Pharmaceutical Chemistry, The Ohio state University Columbus Ohio USA. 18th October. 2016 – March. 2017Oct. 2015-May 2017, (Advisor: Professor Rajgopal Govindarajan)

Postdoctoral Fellow: NanoTherapeutics laboratory, Department of Chemistry, University of Georgia Athens Georgia USA. Sept. 2012-Oct. 2015 (Advisor: Professor Shanta Dhar)

PhD.: Department of Chemistry, Indian Institute of Technology Bombay Mumbai, India. July 2006-Nov. 2011 (Advisor: Professor C. P. Rao)

Research Interest:

In our group we are working on the area of biological in(or)ganic chemistry and nanomedicine, a unique combination of in(or)ganic chemistry, biology and nanotechnology.

Metal-organic nanoscale composites for drug delivery.

Supramolecular containers for molecular recognition and drug delivery.

Multifaceted platinum based therapeutics for cancer.

Publications:

  • Mody, H.; Hung S. W.; Pathak, R.K.; Griffin J.; Cruz-Monserrate Z.; Govindarajan R. (2017) “miR-202 Diminishes TGFbeta Receptors and Attenuates TGFbeta1-induced EMT in Pancreatic Cancer”. Mol. Cancer Res., Published Online First April 3, 2017 doi: 10.1158/1541-7786.MCR- 16-0327. (IF = 4.51, SJR: 2.53)
  • Pathak, R. K.; Wen, R.; Kolishetti, N.; Dhar. S. (2017) "A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer" Mol. Cancer Ther., 16(4), 625-636. (IF = 5.57, SJR: 3.22)

  • Pathak, R. K.; Dhar. S. (2016)"Combined Chemo-Anti- Inflammatory Prodrugs and Nanoparticles" Synlett, 27(11): 1607-1612. (IF = 2.32, SJR: 0.91)

  • Basu, U.; Banik, B.; Wen, R.; Pathak, R. K.; Dhar, S. (2016) “The Platin X-series: Activation, targeting and delivery” Dalton Transaction., 45 (33), 12992-13004. (IF = 4.17, SJR: 1.4)

  • Wen, R.; Banik, B.; Pathak, R. K.; Kumar, A.;Kolishetti, N. and Dhar. S. (2016) "Nanotechnology inspired tools for mitochondria dysfunction related diseases"Adv. Drug Deliv. Rev.99(Part A), 52-69.(IF = 15.04, SJR = 5.2)

  • Pathak, R. K.; Dhar. S. (2016) "Unique use of alkylation for chemo-redox activity by a Pt(IV) prodrug" Chem.Eur. J.,22 (9), 3029-3036. (IF = 5.77, SJR: 2.32)

  • Kalathil, A. A.; Kumar, A.; Banik, B.; Ruiter, T. A.; Pathak, R. K. and Dhar. S. (2016)"New formulation of old aspirin for better delivery "Chem. Commun., 52, 140-143. (IF = 6.56, SJR: 2.77)

  • Feldhaeusser, B. ‡; Platt, S. R.; Marrache, S. ‡; Kolishetti, N. ‡; Pathak, R. K.; Montgomerya, D. J. Reno, L. R.; Howerthd, E.; Dhar. S. (2015)" Evaluation of Nanoparticle Delivered Cisplatin in Beagles" Nanoscale 7, 13822-13830.(IF = 7.76, SJR: 2.97)

  • Pathak, R. K.; Dhar. S. (2015)" A nanoparticle cocktail: Temporal release of predefined drug combinations" J. Am. Chem. Soc.,137, 8324–8327. (IF = 13.03, SJR: 7.12)

  • Pathak, R. K.; Kolishetti, N.; Dhar. S. (2015)" Targeted Nanoparticles in Mitochondrial Medicine" WIREs NanomedNanobiotechnol, 7, 315–329.(IF = 4.1, SJR: 1.45)

  • Marrache, S.; Pathak, R. K.; and Dhar, S. (2015) "Formulation and optimization of mitochondria-targeted polymeric nanoparticles" Mitochondrial Medicine, Methods in Mol. Bio. ; Springer, New York, Vol 1265, 103-12. . (IF = 1.29, SJR in Chemistry: 0.55)

  • Pathak, R. K.,Marrache, S., Choi, J. H., Berding, T. B. and Dhar, S. (2014) "The prodrugPlatin-A: Simultaneous release of cisplatin and aspirin"Angew. Chem. Int. Ed., 53, 1963-1967. (IF = 11.70, SJR in Chemistry: 6.23)

  • Pathak, R. K.; Marrache, S.; Harn, D. A. and Dhar, S. (2014) "Mito-DCA: A mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate" ACS Chem. Biol., 9, 1178-1187.(IF = 5.09, SJR: 2.86)

  • Pathak, R. K.;McNitt, C.; Popik, V. V. and Dhar, S. (2014) "Copper-free click-chemistry platform to functionalize cisplatinprodrugs" Chem. Eur. J., 20, 6861-6865. (IF = 5.77, SJR = 2.32)

  • Marrache, S. ‡; Pathak, R. K. ‡;and Dhar, S. (2014) "Detouring of Cisplatin to Access Mitochondrial Genome for Overcoming Resistance"Proc. Natl. Acad. Sci. USA, 111, 10444-10449. ‡ Equal contribution. (IF = 9.42, SJR: 6.88)

  • Marrache, S. ‡; Pathak, R. K. ‡; Darley, K. L. ‡; Choi, J. H.; Zaver, D.; Kolishetti, N.; Dhar. S. (2013) “Nanocarriers for tracking and treating diseases” Curr. Med. Chem. 20, 3500-3514. (IF = 3.09, SJR: 0.84) ‡ Equal contribution.

  • Mummidivarapu, V.V. S.; Pathak, R. K.; Rao, C. P. (2016) “Structure of a di-zinc complex of abis-calix[4]arene conjugate and its sensing of cysteine among the amino acids”Supramolecular Chemistry. (IF = 2.39, SJR: 0.47)

  • Mummidivarapu, V.V. S.; Pathak, R. K.; Hinge, V. K.; Dessingou, J.; Rao, C. P. (2014)“A fluorescent di-zinc(II) complex of bis-calix[4]arene conjugate as chemosensing-ensemble for the selective recognition of ATP”Supramolecular Chemistry., 26, 538-546. (IF = 2.39, SJR: 0.47)

  • Pathak, R. K.; Dessingou, J.; Hinge, V. K.; Rao, C. P. (2013)“Quinoline driven fluorescence turn on 1,3-di- calix[4]arene conjugate based receptor to discriminate Fe 3+ from Fe 2+ ” Anal. Chem., 85, 7, 3707–3714. (IF = 5.88, SJR: 2.37)

  • Pathak, R. K.; Hinge, V. K.; Rai, A.; Panda, D.; Rao, C. P. “(2012) “Imino-phenolic- pyridyl conjugates of calix[4]arene (L1 and L2) as primary fluorescence switch on sensors for Zn 2+ in solution and in HeLa cells, and the recognition of pyrophosphate and ATP by [ZnL 2 ]” Inorg. Chem. 51, 4994−5005. (IF = 4.82, SJR: 1.87)

  • Pathak, R. K.; Hinge, V. K.; Mondal, P.; Rao, C. P. (2012) “Ratiometric fluorescence off-on- off sensor for Cu 2+ in aqueous buffer by a lower rim triazole linked benzimidazole conjugate of calix[4]arene” Dalton Trans., 41, 10652-10660.(IF = 4.17, SJR: 1.4)

  • Pathak, R. K.; Tabbasum, K.; Rai, A.; Panda, D.; Rao, C. P. (2012) “Pyrophosphate Sensing by a Fluorescent Zn 2+ Bound Triazole Linked Imino-Thiophenyl Conjugate of Calix[4]arene in HEPES Buffer Medium: Spectroscopy, Microscopy, and Cellular Studies” Anal. Chem., 84, 5117−5123. (IF = 5.88, SJR: 2.37)

  • Pathak, R. K.; Hinge, V. K.; Mahesh, K.; Rai, A.; Panda, D.; Rao, C. P. (2012) “Cd 2+ complex of triazole based calix[4]arene conjugate as selective fluorescent chemo-sensor for Cys” Anal. Chem., 84, 6907-6913. (IF = 5.88, SJR: 2.37)

  • Pathak, R. K.; Tabbasum, K.; Rai, A.; Panda, D.; Rao, C. P. (2012) “A Zn 2+ specific triazole based calix[4]arene conjugate (L) as fluorescence sensor for histidine and cysteine in HEPES buffer milieu” Analyst., 137, 4069-4075. (IF = 4.03, SJR: 1.3)

  • Pathak, R. K.; Dessingou, J. Rao, C. P. (2012)“Multiple sensor array of Mn 2+ , Fe 2+ , Co 2+ , Ni 2+ , Cu 2+ and Zn 2+ complexes of a triazole linked imino-phenol based calix[4]arene conjugate for the selective recognition of Asp, Glu, Cys and His” Anal. Chem., 84, 8294-8300.(IF = 5.88, SJR: 2.37)

  • Pathak, R. K.; Tabbasum, K.; Hinge, V. K. Rao, C. P. (2011) “Selective recognition of cysteine in its free and protein bound states by the Zn 2+ complex of triazole based calix[4]arene conjugate” Chem. Eur. J., 17, 13999 – 140000.(IF = 5.77, SJR = 2.32)

  • Pathak, R. K.; Hinge, V. K.; Milon, M.; Rao, C. P. (2011); “Triazole-linked- thiophene conjugate of calix[4]arene: Its selective recognitionof Zn 2+ and as biomimetic model in supporting the events of the metal detoxification and oxidative stress involving metallothionein” J.Org. Chem. 76, 10039−10049.(IF = 4.78, SJR: 2.1)

  • Pathak, R. K.; Dikundwar, A. G.; Guru Row, T. N.; Rao, C. P. (2010) “A lower rim triazole linked calix[4]arene conjugate as a fluorescence switch on sensor for Zn 2+ in blood serum milieu” Chem. Commun., 46, 4345-4347.(IF = 6.56, SJR: 2.77)

  • Pathak, R. K.; Ibrahim, S. M.; Rao, C. P. (2009) “Selective recognition of Zn 2+ by salicylaldimine appended triazole linked di-derivatives of calix[4]arene: Role of terminal –CH 2 OH moieties in conjunction with imine in the recognition” Tetrahedron Lett., 50, 2730-2734.(IF = 2.34, SJR: 0.78)